The phosphate salt of codeine takes place as white, needle-formed crystals or white crystalline powder. Codeine phosphate is freely soluble in drinking water and marginally soluble in alcohol. The molecular excess weight is 406.37. Its molecular formula is C18H21NO3•H3PO4 • ½ H2O, and it has the subsequent chemical structure.
Though it helps Many individuals, this medication includes a risk for abuse and should occasionally cause addiction. This risk may very well be bigger Should you have a compound use dysfunction (for instance overuse of or dependancy to medication/Alcoholic beverages).
The concomitant utilization of anticholinergic drugs with Promethazine with Codeine Oral Resolution may perhaps maximize risk of urinary retention and/or significant constipation, which may result in paralytic ileus [seeWARNINGS AND Safeguards (5.
The usage of Promethazine with Codeine Oral Resolution in clients with acute or significant bronchial asthma within an unmonitored placing or within the absence of resuscitative equipment is contraindicated [seeCONTRAINDICATIONS (four)]. Opioid analgesics and antitussives, including codeine, on the list of Energetic elements in Promethazine with Codeine Oral Alternative, should not be Employed in people with acute febrile ailment connected with successful cough or in sufferers with Serious respiratory disorder in which interference with power to crystal clear the tracheobronchial tree of secretions would've a deleterious impact on the individual's respiratory operate.
Most MAO inhibitors should also not be taken for 2 weeks before remedy with this medication. Question your health care provider when to begin or stop getting this medication.
It's not a whole listing of doable Unintended effects. For those who detect other Unwanted effects not detailed above, check here Call your health practitioner or pharmacist.
Promethazine hydrochloride wasn't mutagenic within the in vitro bacterial reverse mutation assay or clastogenic in the in vitro Chinese hamster ovary (CHO) cell chromosomal aberration assay.
Narcotic analgesics cause histamine launch, which appears to become to blame for wheals or urticaria often observed at the internet site of injection on parenteral administration.
Ensure you understand how to just take this products and what other medicines you need to prevent taking with it. See also Drug Interactions segment. Get professional medical assistance instantly if any of these pretty major Unwanted side effects come about: sluggish/shallow respiration, unconventional lightheadedness, intense drowsiness/dizziness, difficulty waking up.
Promethazine with Codeine Oral Alternative is indicated with the non permanent aid of coughs and upper respiratory indicators affiliated with allergy or the popular chilly in clients eighteen many years of age and more mature.
Codeine triggers miosis, even in overall darkness. Pinpoint pupils are an indication of opioid overdose but are certainly not pathognomonic (eg, pontine lesions of hemorrhagic or ischemic origins might develop similar conclusions). Marked mydriasis as opposed to miosis could possibly be witnessed on account of hypoxia in overdose predicaments.
At the very least a person death was claimed in the nursing infant who was exposed to higher levels of morphine in breast milk since the mom was an ultra-immediate metabolizer of codeine.
When the response to an opioid antagonist is suboptimal or only brief in nature, administer supplemental antagonist as directed because of the solution’s prescribing facts. The respiratory depressant results of promethazine are not reversed by opioid antagonists, for instance naloxone.
The pharmacokinetics of Promethazine with Codeine Oral Option hasn't been characterized in patients with renal impairment. Codeine pharmacokinetics might be altered in patients with renal failure. Clearance might be decreased as well as metabolites may perhaps accumulate to much better plasma stages in individuals with renal failure in comparison with patients with ordinary renal operate.